REVOLUTIONIZING SPERM SELECTION FOR ENHANCED FERTILITY CONTROL

LICENSING & PARTNERING OPPURTUNITIES


The landscape of sperm selection for in vitro fertilization (IVF) is marked by challenges, where conventional methods struggle to identify sperm with optimal competency for fertilization and embryo development. In response, the ZP2 Peptide Beads emerge as a distinctive solution. These beads, incorporating the N-terminal region of ZP2, offer a unique platform for sperm selection. The ZP2 Peptide Beads present specific advantages: a targeted approach to successful sperm binding and penetration, translational studies showcasing superior sperm competency, an abundant source of reagents for selection, and a cost-effective, seamlessly integrated protocol within the IVF lab workflow. This innovation represents a significant step forward in the realm of sperm selection, addressing existing limitations and providing a more nuanced approach to fertility control and assisted reproductive technologies (ART).

The Advantages

  • Biological Relevance: The ZP2 peptide beads emulate the natural process of binding and penetration through the zona pellucida, crucial for fertilization in mice and humans.
  • Selective Competency: Unlike traditional sperm selection methods, this approach identifies and selects a subpopulation of human sperm with superior competency for fertilization and embryo development.
  • Reversibility and Superior Viability: The initial reversible binding of sperm to the ZP2 peptide beads opens avenues for short-term selection, preserving sperm motility and competency..

APPLICATIONS

  • Targeted N-Terminal Region: The focused identification of a single domain at the N-terminal region of ZP2 distinguishes our selection assay, ensuring specificity for successful sperm binding and penetration.
  • Translational Studies: Extensive translational studies demonstrate the superior competency of sperm selected through ZP2 peptide beads, presenting better viability, motility, and morphology.
  • Unlimited Reagents: The ZP2 peptide beads offer an unlimited volume of reagents for sperm selection, overcoming the challenges of limited resources in traditional methods. Cost-Effective and Seamless Integration: The relative simplicity, limited costs, and seamless integration into the IVF lab workflow provide additional advantages over existing selection protocols.

COMMERCIALIZATION OPPORTUNITY

For more information, please contact:TechTransfer@sidra.org

Inventors

Matteo Avella

Sidra Medicine